Take the guesswork out of functional studies by directly linking imaging and gene expression data from the same individual cells.
A Flexible, High-Throughput Approach combining Single-Cell Phenotyping and Transcriptomics
Our platform links cell behavior to molecular identity, all in a single workflow.
The FLEX chip captures individual cells in a microscope-ready picowell array, allowing you to run your chosen assay—such as cell culture, functional tests, or imaging— directly on the chip. You can then perform molecular analyses like RNA-seq on the same sample, preserving single-cell resolution and linking every readout back to its cell of origin.
Our Technology, Your Biology
Built for flexibility. Powered by single-cell precision.
The FLEX consumable is designed for scalable, functional single-cell experiments that adapt to your biology, not the other way around. From high-throughput imaging to targeted transcriptomic barcoding, our platform brings integration and simplicity to every step.
- Function-first: optimized for live-cell assays, antigen screening, and phenotyping
- Microscope-ready: use with any inverted fluorescence microscope
- 8-site design: multiplex up to 8 samples per chip
- 384-well format: standard layout for familiar workflows
- SBS spacing: compatible with multichannel pipettes and automation
The Flexomics Workflow
Load
Smart loading. Zero hassle
- Tunable Cell Loading: Each site contains ~80,000 mapped wells for precise single-cell isolation. Capture 10,000-20,000 cells per site or sequentially load different cell types for co-culture experiments.
- Multi-Sample Processing: Run up to 8 samples simultaneously on a single consumable, no batching required.
- No Custom Equipment: The FLEX picowell consumable relies on simple and elegant gravity-based microfluidics — all you need is a pipette!
Culture
Effortless on-chip cell culture.
- Easy On-Chip Culture: Culture cells directly on the FLEX consumable for 4+ days, no transfers or special steps required.
- Incubator-ready: Compatible with standard CO₂ incubators and commonly used media and reagents.
Run Your Live Cell Assays
Miniaturize your workflow. Maximize your insight.
- Functional Live Cell Assays: Deliver reagents directly onto captured cells to perform assays such as:
- Immunofluorescence
- Proliferation/survival
- Cytokine signaling
- Cell-cell interaction
- Neoantigen discovery
… and more!
- Customizable by design: FLEX technology adapts to your assay, not the other way around. Contact us to explore custom workflows tailored to your biology.
Image Cellular Response
High-quality imaging. Built into your workflow.
- Live-cell imaging made easy: Capture brightfield and fluorescence images directly on the FLEX chip, no transfers required.
- Track single cells over time: Unique well reference markers enable reliable cell tracking across multiple timepoints and days.
- Microscope-friendly format: Designed to fit standard slide holders; compatible with most inverted fluorescence microscopes (up to 40X objectives).
Sequence
Well-level resolution. Flexible readouts.
- NGS your way: From whole transcriptome to targeted RNA-seq, short- or long-read: FLEX supports a range of sequencing strategies to fit your study.
- Built-in barcoding: Each consumable is pre-loaded with digitally mapped RNA capture beads for precise single-cell labeling and tracking across all wells
Analyze
Multi-modal insights. No code required.
- Integrated exploration: FLXplorer links imaging and sequencing data at the single-cell level: browse, compare, and interrogate your data in one place.
- Visualize and annotate: Define cell populations, generate plots, and overlay phenotypic and molecular data to uncover deeper biological insights.
Technology Highlights
Convenient Cell Culture
Culture cells directly on the FLEX chip using standard CO₂ incubators, no special equipment or protocols required.
Microscope Compatibility
Use the FLEX platform with your existing inverted fluorescence microscopes, no costly hardware upgrades needed.
Assay Adaptability and Miniturization
Easily miniaturize and adapt your fluorescence-based assays, while integrating with RNA sequencing.
Same-Cell Data Collection
Capture both imaging and sequencing data from the same individual cell, enabling confident, high-resolution functional-genomic insights.
Multi-Modal Data Integration
Link phenotypic and transcriptomic data across timepoints, assays, and modalities to generate unified single-cell profiles.
FLXplorer Analysis Dashboard
Explore, annotate, and visualize your data with our intuitive, code-free FLXplorer dashboard designed for fast, flexible analysis.
